Scientist, Mammalian Cell Biology

Inscripta | Industry | Boulder, CO | More →

Inscripta was founded in 2015 and recently launched the world’s first benchtop Digital Genome Engineering platform. The company is growing aggressively, investing in its leadership, team, and technology with a recent $150mm financing round led by Fidelity and TRowe price. The company’s advanced CRISPR-based platform, consisting of an instrument, reagents, and software, offers a fully automated workflow that enables multiplexed, trackable editing of cells at an unprecedented scale. Inscripta’s mission is to enable scientists to realize the full potential of biology. Due to rapid growth and recent commercialization, Inscripta has an opening for a Scientist, Mammalian Cell Biology, located in our Boulder, CO office.

Summary:
As a Scientist in the Mammalian Cell Biology group, you will be part of a diverse team focused on advancing the development of Inscripta’s cell engineering platform. The ideal candidate will develop and implement high-throughput screening strategies in human primary cells, enabling the discovery and optimization of genome engineering tools. In this role, you will be a leader in bringing new and innovative technologies and processes to market and will be responsible for planning, executing and reporting on experiments from a world class team of Engineers, Biologists, and Computer Scientists.

Responsibilities:
• Apply high-throughput screening approaches to interrogate cellular processes in primary human cells.
• Design, execute, and analyze experiments to advance Inscripta’s mammalian cell engineering program.
• Build assays that allow the genetic, phenotypic, and functional characterization of engineered mammalian iPSCs, primary immune cells, and/or other cell types.
• Develop and optimize workflows for high-throughput genome engineering in primary human cell types.
• Identify innovative solutions to solve key scientific challenges required for program success.
• Drive effective communication and collaboration within a multidisciplinary team of scientists and engineers to advance program objectives.
• Demonstrate integrity, positivity, and a team-oriented attitude and motivate others to do the same.

Requirements:

Required Qualifications:
• Ph.D in cell biology, immunology, biochemistry, developmental biology, molecular biology, or a related discipline.
• 2+ years in postdoc or industry setting.
• Direct experience working with genome editing tools in mammalian cells.
• Expert in high-throughput assays, especially adapting or utilizing methods on automated equipment.
• Expert in primary human cell culture techniques.
• Proficiency in gene delivery methods, e.g., transfection, lentivirus, rAAV, etc.
• Demonstrated ability to work both independently and within matrixed project teams.
• Excellent written and oral communication skills.
• Exceptional data analysis and quantitative skills.
• Track record of creativity and problem-solving.

Preferred Qualifications:
• Independence using automated liquid handling platforms.
• Experience with large-scale screening efforts.
• Deep understanding of genome integrity and mechanisms that promote mammalian genome stability.
• Specialized expertise in the derivation, culture and characterization of primary human immune cells, human pluripotent stem cells, keratinocytes, hepatocytes, and/or neurons.

Inscripta offers a competitive base salary, bonus plan, benefits package, 401k match and an attractive equity program to all team members. Join us and work with a cutting edge organization creating cutting edge technology. At Inscripta we don’t just accept difference — we celebrate it, support it, and thrive on it for the benefit of our employees, our innovation, and our community. We are proud to be an equal opportunity workplace because the more inclusive we are as a company, the better our work will be. Inscripta is headquartered in Boulder, CO with offices in Pleasanton and San Diego, CA. This position is located in our Boulder headquarters office.