Activities

  • Enabling Quality, Measurable Synthetic DNA Sequence Screening

    This project aims to improve DNA synthesis screening by enabling the development of better tools and mechanisms for screening performance evaluation. Synthetic DNA enables life sciences research that can be applied to pressing societal challenges across many sectors, but could also be used in the development of biological parts, systems, or organisms that cause great harm to human, public, or environmental health. Many companies that produce and sell synthetic DNA screen ordered sequences to prevent customers from inappropriately accessing Sequences of Concern (SOCs). However, they lack tools to evaluate the performance of their screening systems. Such tools are crucial as technical capabilities in engineering biology, artificial intelligence, and other areas grow.

  • End-to-End Stress Testing (E2EST) of DNA Synthesis Screening

    DNA synthesis is a powerfully enabling capability for engineering biology to address important challenges across sectors, but as these capabilities become more accessible, the biosecurity risks they pose rises. In 2024 and 2025, EBRC, with support from Sentinel Bio, will conduct end-to-end stress testing (E2EST) of nucleic acid synthesis providers. We will use customers with different attributes and sequences with different biorisk profiles to learn about provider customer, sequence, and follow-up screening practices.

  • Building International Best Practices For Robust Synthetic Nucleic Acid Screening

    This project aims to establish a set of internationally recognized best practices for nucleic acid synthesis screening through a coordinated global approach. By engaging with academic, industry, government, and non-profit stakeholders, this initiative will build on EBRC’s previous work to enhance biosecurity and ensure screening practices are robust and resilient to evolving technological risks.

  • Malice Analysis: Assessing Biotechnology Research for Security Concerns

    EBRC’s Malice Analysis program trains researchers and others associated with engineering biology to critically evaluate research for potential security concerns. By providing practitioners with the tools and a framework to conduct basic security analyses, EBRC hopes to support a culture in the field of engineering biology that incorporates the consideration and discussion of security into the research and development life-cycle.

  • Global Forum for Engineering Biology

    The EBRC Global Forum for Engineering Biology is an initiative dedicated to fostering collaboration, information exchange, and the development of national strategies for synthetic and engineering biology. The Global Forum aims to be an ongoing platform for dialogue and action, bringing together experts, policymakers, and leaders to advance the global bioeconomy. As part of this initiative, EBRC convenes international summits, develops resources, and supports international efforts aimed at addressing key global challenges such as standards, security, and sustainability.

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