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John Glass

Dr. John Glass is a Professor and leader of the J. Craig Venter Institute (JCVI) Synthetic Biology and Bioenergy Group. His expertise is in molecular biology, microbial pathogenesis, RNA virology, and microbial genomics. Glass is part of the Venter Institute team that created the first bacterial cell with a chemically synthesized genome and a bacterial cell with a synthetic genome encoding only the essential gene set needed for life. In reaching this milestone the Venter Institute scientists developed the fundamental techniques of the new field of synthetic genomics including genome transplantation and genome assembly. Glass was also leader of the JCVI project that rapidly made synthetic influenza virus vaccine strains in collaboration with Novartis Vaccines and Diagnostics, Inc. and Synthetic Genomics, Inc. At the JCVI he has also led the bacterial outer membrane vesicle based vaccine, genome transplantation, and Mycoplasma genitalium minimal genome projects, and projects studying other mycoplasma and ureaplasma species. Glass and his Venter Institute colleagues are now using synthetic biology and synthetic genomics approaches developed at the JCVI to create cells and organelles with redesigned genomes to make microbes that can produce biofuels, pharmaceuticals, and industrially valuable molecules. Glass is an adjunct faculty member of the University of Maryland at College Park Cellular and Molecular Biology Program, one of the founding members of the Build-A-Cell program to create synthetic cells, and member of the Global Viral Network Scientific Leadership Board.

Prior to joining the JCVI, Glass spent five years in the Infectious Diseases Research Division of the pharmaceutical company Eli Lilly. There he was a member of the hepatitis C virology group and a microbial genomics group (1998-2003). There Glass was part of the Lilly and Vertex Pharmaceuticals Inc. team that developed Incivek, one of the first drugs to cure hepatitis C virus.
Glass earned his undergraduate (Biology) and graduate degrees (Genetics) from the University of North Carolina at Chapel Hill. His Ph.D. work was on RNA virus genetics in the laboratory of Gail Wertz. He was on the faculty and did postdoctoral fellowships in the Microbiology Department of the University of Alabama at Birmingham in polio virology with Casey Morrow and mycoplasma pathogenesis with Gail Cassell (1990-1998). On sabbatical leave in Ellson Chen’s lab at Applied Biosystems, Inc. (1995-1997) he sequenced the genome of Ureaplasma parvum and began his study of bacterial genomics.

Andrew Ellington

The Ellington lab works on using synthetic biology to augment organismal chemistry, generating expanded genetic alphabets and genetic codes. In addition, we attempt to developing orthogonal control systems for a variety of organisms that allow us to readily lay in new instruction sets that can operate on top of normal metabolism. Between these innovations, it has proven possible to develop and produce novel biomaterials, with the ultimate goal of being able to direct the evolution of materials properties.

James Diggans

James Diggans is Director, Data Science and Biosecurity for Twist Bioscience, a DNA synthesis company based in San Francisco, CA. He holds a PhD from George Mason University in Computational Biology and Bioinformatics and has worked in target discovery, molecular diagnostic development and biodefense including five years leading the computational biology group at the MITRE Corporation. His research has included methods for efficient detection of biological weapons release, machine learning-based cancer diagnosis, and novel algorithmic approaches to discerning intent in oligonucleotide-length DNA synthesis requests. At Twist, his group builds cloud-based bioinformatics systems for effective biosecurity screening and analysis of next generation sequencing data to power silicon-based DNA synthesis at record scale.

Vincent Noireaux

Vincent Noireaux got his B.Sc. in applied physics at the University of Tours (France) in 1994. In 1995 he moved to Paris for physics graduate school at the University Paris 11 (Orsay). He did his PhD at the Curie Institute (Paris, 1996-2000) in biological physics in the laboratory of Jacques Prost on the motion of the bacterium Listeria. He studied the actin cytoskeleton mechanisms involved in cell motility and learned the biology related to this project in the laboratory of Daniel Louvard. In 2000 he joined the laboratory of Albert Libchaber at the Rockefeller University in New York City where he spent five years as a postdoc. He used cell-free expression systems to construct elementary gene networks and synthetic cell systems. In 2005, he moved to the University of Minnesota where he is pursuing his work in synthetic biology using cell-free expression. His research consists of constructing and characterizing biochemical systems by executing synthetic DNA programs in vitro, from simple regulatory elements to synthetic cells.

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John Glass

Andrew Ellington

James Diggans

Vincent Noireaux

Christopher Anderson