• Introduction to Engineering Biology: A Conceptual Framework for Teaching Synthetic Biology

    Publication Date: June 2023 | Originally published in ACS Synthetic Biology

    This publication is a companion piece to our Introduction to Engineering Biology curriculum module that was created and released in 2022.

  • Security Considerations at the Intersection of Engineering Biology and Artificial Intelligence

    Publication Date: November 2023

    This white paper describes three areas at the intersection of engineering biology and artificial intelligence that may yield significant security concerns: de novo biological design, closed-loop autonomous laboratories, and natural language Large Language Models. It describes each area, identifies potential security concerns, and offers ideas for the potential mitigation of those concerns, ultimately calling for an international forum to continually address this evolving issue.

  • Potential Changes to the Policies for Oversight of DURC and the P3CO Policy Framework

    Publication Date: October 2023

    Potential Changes to the Policies for Oversight of Dual Use Research of Concern (DURC) and the Potential Pandemic Pathogen Care and Oversight (P3CO) Policy Framework: An EBRC Response to OSTP RFI 88 FR 60513.

  • Identifying Ambiguities, Gaps, Inefficiencies, and Uncertainties in the Coordinated Framework for the Regulation of Biotechnology

    Publication Date: February 2023

    Identifying Ambiguities, Gaps, Inefficiencies, and Uncertainties in the Coordinated Framework for the Regulation of Biotechnology: An EBRC Response to OSTP RFI 87FR77900

  • National Biotechnology and Biomanufacturing Initiative: An EBRC Response to OSTP RFI 87FR77901

    Publication Date: January 2023

  • NIST RFI on Implementation of US National Standards Strategy

    Publication Date: November 7

    EBRC’s response to the request by NIST to support the Implementation of the United States Government National Standards Strategy for Critical and Emerging Technology (USG NSSCET). With a focus on engineering biology technologies, we provide critical considerations for engaging private sector stakeholders in transparent, equitable, and accessible standards development activities.

  • Request for Information on Developing a Roadmap for the TIP Directorate at the National Science Foundation

    Publication Date: July 2023

    EBRC’s response to the request by the NSF for comments on the development of a roadmap to guide investment decisions of the newly formed TIP Directorate. We recommend prioritizing engineering biology research through infrastructure development, data programs, and equitable workforce initiatives to strengthen biotechnology translation and U.S. economic competitiveness. We also highlight the several crosscutting areas for investments where engineering biology overlaps with other TIP areas of interest, such as AI, materials science, climate change, and advanced robotics.


  • Biological Carbon Capture and Conversion

    Publication Date: July 2023

    Engineering biology applications could contribute to significant emission cuts and move us toward achieving climate goals by replacing fossil fuels and fossil fuel-derived products with biobased products, transforming agriculture and industries with the introduction of low-emission and eco-friend processes and products, and building climate resilience for urban and rural communities.

  • Microbiome Research Strategy

    Publication Date: July 2023

    Recent advances in data science and engineering biology have accelerated the capabilities of microbiome engineering research. To harness these new capabilities and boost innovation, EBRC highlights technical methods, computational tools, testbed infrastructure, and data sharing requirements are in need of federal investment. These efforts should be coordinated across the Federal Government to capitalize on momentum and bolster productivity throughout the field.

  • Biocontainment Policy in a Robust Bioeconomy

    Publication Date: July 2023

    Deployed engineering biology products have the potential to reshape our environment, agriculture, human health, and more. Such impactful applications necessitate operation outside of traditional biocontainment vessels and thus require renewed biocontainment policies. Herein, EBRC highlights emerging biocontainment research, areas for investment, and horizon scanning activities to promote safe and responsible biotechnology innovation.

  • Request for Information on Future Topics for Workforce Development in Emerging Technology Career Pathways

    Publication Date: June 2023

    Response submitted by EBRC Director of Roadmapping and Education, Dr. Emily Aurand, to the request by NSF seeking novel approaches that lead to the recruitment of diverse and creative individuals into emerging technologies. This response provides strategic recommendations to increase the rate and composition of students enrolled in both traditional and non-traditional academic pathways to STEM and high-paying technology careers.


  • An Assessment of Short-Term Milestones in EBRC’s 2019 Roadmap, Engineering Biology

    Publication Date: March 2023

    The 2019 EBRC roadmap, Engineering Biology: A Research Roadmap for the Next-Generation Bioeconomy, extensively cataloged the potential for progress in the field, setting out numerous goals, possible breakthroughs, and ambitious milestones for the following 20 years. As we approached and passed the first milestone timepoint at 2-years post publication, EBRC sought to review progress in the field, compared against the advancements anticipated by the roadmap. This resulting Assessment reports on technical achievements and advancements and to barriers to progress, enabling the community to reflect on its achievements and identify areas for additional investment and infrastructure to ensure continued advancement.

  • Moonshots for the 21st-Century Bioeconomy

    Publication Date: December 2022

    In response to the Bioeconomy Executive Order, EBRC envisions moonshots for achievements in engineering biology across five sectors, highlighting the promise and potential of biotechnology. We also link to our interactive EBRC roadmaps, which provide more expansive visions of the innovations that are possible through engineering biology research and application.

  • Standards and Metrics to Accelerate the Global Bioeconomy

    Publication Date: December 2022

    Common language, measurements, and widely adopted standards are critical for many activities within the bioeconomy. We identify challenges, next steps, and recommendations for establishing standards and metrics to promote a secure and robust bioeconomy.

  • Regulatory Clarity, Communication, and Nimbleness

    Publication Date: December 2022

    The United States is at the forefront of the biotechnology revolution, and its regulatory agencies are and will continue to be tasked with establishing and enforcing rules and regulations that ensure the commercialization of biotechnologies that are viable and economically-sound solutions and do not present unacceptable risk. Herein articulate select areas of uncertainty and concern that have caused challenges in the development of biotechnologies.

  • Platform Vulnerabilities and Security in the Bioeconomy

    Publication Date: December 2022

    Platform technologies enable the research, development, and commercialization of biotechnologies, but may be vulnerable to exploitation. We identify platforms that support different segments of the bioeconomy and discuss their vulnerabilities, how those vulnerabilities might be exploited, and actions the U.S. Government can take to support a secure bioeconomy.

  • Biosafety & Biosecurity Innovation Initiative

    Publication Date: December 2022

    EBRC proposes a structure and function of a Biosafety & Biosecurity Innovation Initiative to reduce biological risks associated with a growing bioeconomy. We recommend that priorities and best practices for a safe and secure bioeconomy be identified through consistent communication between federal agencies and stakeholders across the bioeconomy enterprise.

  • Development of a Workforce to Support a Distributed, Equitable Bioeconomy

    Publication Date: December 2022

    The development of biotechnologies that will usher in a more sustainable and healthier future require a talented, trained workforce that reflects the diversity of America. The bioeconomy will rely on the distribution of opportunity geographically, demographically, and across the workforce spectrum.

  • Educating the Next-Generation Bioeconomy Workforce

    Publication Date: December 2022

    A robust and distributed bioeconomy requires a skilled, diverse workforce. We describe opportunities and recommendations for improving education and training of the next-generation of biotechnology leaders.

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