DGOF Research elements of EO 14292: Improving the Safety and Security of Biological Research

Publication Date: July 2025

The Trump Administration released Executive Order 14292: Improving the Safety and Security of Biological Research in May 2025. The EO directed the Office of Science and Technology Policy (OSTP) to develop new policy for “dangerous gain of function” research (DGOFR) to supercede a 2024 policy framework. This EBRC comment encourages the development of a transparent, implementable policy with a precise and narrow definition of DGOF.

Keywords: dangerous gain-of-function research, DGOFR, biosecurity policy, responsible research

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