Response to RFI on NIST AISI’s Draft Document: Managing Misuse Risk for Dual-Use Foundation (AI) Models

Publication Date: March 2025

EBRC’s response to NIST’s Request for Comment regarding their draft document: “Managing Misuse Risk for Dual-Use Foundation Models.” Protecting technologies against potential misuse is critical for both scientific advancement and public safety. We support the updated document and recommend that NIST’s AI Safety Institute continues this work by collaborating with the scientific community to: 1) Better characterize risks specific to specialized chemical and biological design tools; and, 2) Develop targeted mitigation strategies that protect innovation while preventing misuse.

See the Request for Comment as published in the Federal Register Vol. 90, No. 9 pg 3798.

Keywords: AIxBio, NIST, AI, CBRN, biosecurity, risk, misuse, RFI, ML, LLM

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