Publication Date: June 2022
EBRC’s response to the request by HHS ASPR for comments on the Screening Framework Guidance for Providers and Users of Synthetic Oligonucleotides. EBRC convened a two-day workshop with stakeholders from academia, industry, and government to consider the Guidance, and the discussions that ensued formed the basis for this response.
Keywords: DNA synthesis; oligonucleotide screening; benchtop synthesis; security
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Meagan is a PhD student in the Jewett Lab at Northwestern University. Her research focuses on improving cell-free protein synthesis systems in order to rapidly design and manufacture medical therapeutics. She completed her B.S. in chemical engineering at the University of Arkansas. Outside of the lab, Meagan enjoys cooking, reading, and hiking.
Dr. Woolston joined the NEU Chemical Engineering department as an Assistant Professor in January 2020. As an NSF Graduate Research Fellow, Dr. Woolston received his PhD in Chemical Engineering in 2017 from MIT under the guidance of Prof. Greg Stephanopoulos, where his research focused on the development of genetic tools to enable metabolic engineering in anaerobic CO2-fixing microbes, and the establishment of a methanol utilization pathway in the model organism Escherichia coli. While at MIT, he was an inaugural Fellow of the Chemical Engineering Communication Lab, where he provided peer tutoring and department-wide workshops to assist students and post-docs with aspects of scientific communication. His Post-doctoral work was conducted in the laboratory of Prof. Emily Balskus in the Chemistry & Chemical Biology department at Harvard University, where he studied microbial metabolic pathways and enzymes that contribute to the stability of health-associated Lactobacilli in the human vaginal microbiota. At Northeastern, his research program combines approaches from his previous research training in metabolic engineering, synthetic biology, biochemistry and microbiology to engineer microbes for biofuel & biochemical production, and as diagnostics and therapeutics in the Human gut microbiota. His lab team currently consists of five PhD students and five undergraduates. Since joining NEU, Dr. Woolston has taught the Biochemical Engineering senior elective (CHME 5630) and the graduate course in Kinetics & Reactor Design (CHME 7340). He was the winner of the 2020 IMES Jay Bailey Award young investigator award, as well as the 2021 Biotechnology & Bioengineering Daniel I.C. Wang award.
Degree in Biology from the Universidad Veracruzana, Mexico. Master’s degree in Bioethics from the Anahuac University, Mexico. Doctorate in Sciences from the Scientific Research Center of Yucatán A.C., Mérida, Yucatán. Mexico. Postdoctoral fellow at the Donald Danforth Plant Science Center. St.Louis Missouri, United States.
Currently:
-Titular Type A Researcher at the Center for Research and Assistance in Technology and Design of the State of Jalisco A.C. (CIATEJ), Zapopan Headquarters. Department of Industrial Biotechnology, Zapopan, Jalisco, Mexico. Distinction by the National System of Researchers (SNI I).
-General Coordinator of the “National Network of Synthetic Biology of Mexico”.
-Coordinator of the research sub-line “Synthetic Biology” within the Department of Industrial Biotechnology of the Center for Research and Assistance in Technology and Design of the State of Jalisco A.C. (CIATEJ). In the working group, state-of-the-art sequencing (Oxford Nanopore Technologies) is performed in yeast and bioinformatic analysis of omics data (genome, transcriptome, metagenome). Design of transformation systems through synthesis and Gibson assembly. We use CRISPR-Cas9, dCas9 and Cas13, in order to edit or regulate genes to check functionality in cell lines of animals, bacteria, yeast, marine organisms and plants.