PhD in Biomolecular Science and Engineering at UC Santa Barbara; Post-doc in biological engineering at Northwestern University with Dr. Michal Jewett. My research group aims to integrate biological engineering with hypothesis driven science to advance our understanding of human biochemistry and physiology. A major thrust of my research group focuses on adapting biotechnologies for the classroom to enable inquiry-based learning.
Dr. Jeffrey E. Barrick is an Associate Professor of Molecular Biosciences and a member of the Center for Systems and Synthetic Biology at the University of Texas at Austin. He received his B.S. degree in Chemistry from the California Institute of Technology in 2001 and his Ph.D. degree in Molecular Biophysics and Biochemistry from Yale University in 2006. Dr. Barrick performed his thesis research on the discovery and characterization of metabolite-sensing riboswitches in bacteria under the direction of Ronald Breaker. He was then a postdoctoral fellow from 2006 to 2010 with Richard Lenski at Michigan State University where he studied genome dynamics in a 25-year laboratory evolution experiment with Escherichia coli. His honors include an NSF CAREER Award, an NIH Pathway to Independence Award, and an RNA Society/Scaringe Young Scientist Award. Dr. Barrick’s research is at the interface of synthetic biology and microbial experimental evolution. His laboratory is interested in improving the reliability of biological engineering by developing methods to anticipate and prevent unwanted evolution of designed DNA sequences, in understanding how expanded genetic codes impact the evolutionary potential of organisms, and in engineering insect-associated bacterial symbionts for applications in agriculture. They create and maintain open-source software tools for identifying mutations in microbial genomes from next-generation DNA sequencing data (breseq) and for predicting DNA sequences prone to unwanted evolution (EFM Calculator).
Synberc: Building the Future with Biology (Synberc 10 Year Book)
Synberc was a multi-university research center established in 2006 and funded for ten years with a grant from the National Science Foundation (NSF) to help lay the foundation for synthetic biology. During its 10 years of NSF support, Synberc made important early contributions to the development of the field of synthetic biology through research from members’ labs, interactions between academic and industry members, and broad-impact activities to support socially responsible innovation. At the conclusion of Synberc’s grant period, the Engineering Biology Research Consortium (EBRC) was founded. Many of the key activities established by Synberc have been adopted, improved, and continued by EBRC. EBRC is continuing to develop additional new activities and programs to support and sustain the impact of research, products, discoveries, and ideas from the synthetic biology community.
Synberc’s mission was threefold:
Just as electrical engineers have made it possible to assemble computers from standardized parts (hard drives, memory cards, motherboards, and so on), Synberc envisioned a day when biological engineers systematically assembled biological components such as sensors, signals, pathways, and logic gates to build bio-based systems that solve real-world problems in health, energy, and the environment.
Synberc researchers applied engineering principles to biology to develop tools to improve how fast — and how well — synthetic biologists could go through the design-test-build cycle. These included smart fermentation organisms that can sense their environment and adjust accordingly, and multiplex automated genome engineering, or MAGE, designed for large-scale programming and evolution of cells. Synberc also pursued the discovery of applications that would lead to significant public benefit, such as synthetic artemisinin, an anti-malaria drug that costs less and is more effective than former plant-derived treatment.
In 2006, motivated by the possibility that microbes could be systematically engineered to produce virtually any product from sugar, a group of leading synthetic biologists successfully proposed Synberc to the National Science Foundation. Synberc was a ten-year multi-institutional research project working to lay the foundations for the field of synthetic biology which was emerging at the time. Synberc grew a trusted network of academic researchers working on foundational tools and technologies with a research program that created the enabling tools and technologies that have given rise to many bio-based applications. Synberc’s integrated Policy & Practices group developed and promoted leading examples of responsible synthetic biology research and application in four areas: biosafety and biosecurity; environmental applications and regulation; ownership, sharing and innovation; and community and leadership development. Synberc also built a robust industry partnership that includes nearly 50 small and large companies, non-profits, and industry associations.
With its federal funding ending in 2016, Synberc called upon the federal government to work with academic and industrial researchers to launch a national initiative in engineering biology and thus the Engineering Biology Research Consortium (EBRC) was launched to sustain and coordinate federal investments, coordinate regulatory and safety policies, catalyze public-private partnerships, and encourage education programs to create leaders in biotechnology practice and policy.
Synberc’s research programs focused on projects that developed the foundational understanding and technologies needed to routinely build large numbers of useful biological systems from standard interchangeable parts. Synberc also developed a set of collaborative, cross-cutting testbed projects that drove the development of tools and technologies, and provided proof of principle in building complex applications for real-world problems.
Synberc’s research program focused on the development of:
PARTS – The most basic unit in the design of synthetic biological systems
DEVICES – Engineered genetic objects that are designed to function under specified conditions, and that can be created by combining parts
CHASSIS – Host cells that are designed to run a genetic program.
PRACTICES – Policies, procedures and ways of thinking about ethical, legal and social issues, as well as safety and security.
TESTBEDS – Synberc developed several testbeds to test the integration of Parts, Devices, Chassis and Practices into an integrated application to solve a particular societal challenge. These testbeds ranged from tumor-destroying bacteria to chemical-producing microbes to nitrogen-fixing plants. Many of these testbeds were inspired by industry needs.
Synberc’s specific goals were to:
In addition to the thrusts and testbeds highlighted above, Synberc developed a core of cross-cutting research that provided foundational tools and technologies to advance synthetic biology internally and externally. These projects include automated DNA construction, models and design, safety and security, and registries and repositories.
Synberc facilitated the development of a number of research resources for the synthetic biology community. These resources can be accessed on the EBRC Resources page.
The Meyer lab performs research targeted at re-engineering bacteria to synthesize bio-inspired materials with improved properties. This approach has the potential to replace traditional chemical approaches that require extreme environmental conditions, expensive equipment, and the generation of hazardous waste. As a first step we have targeted bacterial production of patterned artificial nacre, a biomineralized material lining seashells that combines high mechanical strength with high fracture toughness. Combination of our biological materials-producing systems with our newly developed 3D bacterial printers will allow the rapid and straight-forward production of spatially structured biomaterials.
Dr. Sarah Glaven is a research biologist at the U.S. Naval Research Laboratory (NRL) with over 12 years of experience in the field of microbial electrochemistry and electromicrobiology, processes in which microorganisms are used to catalyze electrode reactions and transport electrons over micron size distances. Dr. Glaven is recognized worldwide as an expert in the basic science of this field and for her recent work using meta-omics to understand electron transfer and carbon fixation of a marine cathode bacterial biofilm community. Dr. Glaven has published over 35 peer-reviewed articles in microbial electrochemistry, work that has been cited over 1400 times. She also holds a patent on the use of biocathodes for microbial reductive dechlorination in contaminated groundwater (#8,277,657, “Systems and methods for microbial reductive dechlorination of environmental contaminants”). More recently, Dr. Glaven has begun incorporating tools and practices of synthetic biology in her research to engineer extracellular electron transfer (EET). She also currently serves on the editorial board of ASM’s mSystems, the new journal Biofilms, and is the current President of the International Society for Microbial Electrochemistry and Technology (ISMET).
This workshop is an invitation-only event.
One Chaminade Lane, Santa Cruz, CA 95065
The EBRC Global Forum is an international summit on national synthetic biology roadmaps and strategies. Our goal is to bring together leading representatives from more than 15 countries with active synthetic biology national strategies, programs, and roadmaps. It is an opportunity for international leaders in the field to present and discuss national strategies for synthetic or engineering biology in a relaxed, not-for-attribution forum.
The agenda of two full days includes plenary sessions to exchange information and to review key international and national trends, developments, and themes shaping engineering biology strategies and policies worldwide. We will also hold discussions focused on the common elements, opportunities and challenges for collaborative activities and initiatives that will advance synthetic biology/engineering biology as a global enterprise and exploration into the creation of a virtual and ongoing Global Forum for Engineering Biology.
The Forum is an invitation-only event to be held at the Chaminade Resort & Spa in Santa Cruz, California, USA. Registration fee includes hotel accommodations, meals, and a reception.
The closest airports are San Jose International Airport – SJC (34 miles) or San Francisco International Airport – SFO (62 miles).
Ground transportation to and from SJC or SFO:
Sub Shuttle (www.subshuttle.com) +1-866-256-8182
Santa Cruz On Time Airport Car (www.santacruzontimeairportshuttle.com) +1-831-421-9999
Blue Water Limo (www.bluewater.limo) +1-831-477-0170
Santa Cruz Airport Flyer (www.santacruzflyer.com) +1- 831-423-5937